Biopharmaceutics and pharmacokinetics of [D-ala2, D-leu5]enkephalin after various routes of administration

Biopharmaceutics and Pharmacokinetics

Pharmacokinetics of different routes of administration of misoprostol.

BACKGROUND The pharmacokinetic parameters of four different routes of administration of a single dose of 400 microg of misoprostol were studied. METHODS A total of 40 women undergoing termination of pregnancy by suction evacuation was randomized by computer model to receive 400 microg of misoprostol by one of four routes: (i) sublingual (ii) oral (iii) vaginal and (iv) vaginal with addition o...

Pharmacokinetics of Alternative Administration Routes of Melatonin: A Systematic Review

Introduction ▼ Melatonin is a hormone produced by the pineal gland, regulating the circadian rhythm in mammals [1]. Exogenous administration of melatonin improves sleep quality [2], reduces jet lag [3], and possesses analgesic [4, 5], anti-oxidative [6, 7] and anti-inflammatory effects [6]. Melatonin is traditionally administered orally, but the drug displays a poor and variable bioavailability...

Pharmacokinetics and Biodistribution of Pegylated Methotrexate after IV Administration to Mice

The efficacy of methotrexate (MTX) as an antimetabolite chemotherapeutic agent highly depends on its blood circulation half-life. In our previous study, different conjugates of MTX (MTX-PEG) were synthesized, their physicochemical properties were investigated and MTX-PEG5000 was finally selected as optimum drug-conjugate for further investigations. In the current work, first the stability of MT...

Pharmacokinetics of Alternative Administration Routes of Melatonin: A Systematic Review.

BACKGROUND Melatonin is traditionally administered orally but has a poor and variable bioavailability. This study aims to present an overview of studies investigating the pharmacokinetics of alternative administration routes of melatonin. METHODS A systematic literature search was performed and included experimental or clinical studies, investigating pharmacokinetics of alternative administra...